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Rev. gastroenterol. Perú ; 30(1): 33-39, ene.-mar. 2010. tab
Article in Spanish | LILACS, LIPECS | ID: lil-558993

ABSTRACT

Introdución : La prevalencia de Helicobacter pylori (HP) en Perú tiende a disminuir en niveles socioeconómicos medio y alto. No ha sido evaluada recientemente. Se estudia pacientes de la Clínica Ricardo Palma (CRP), Para evaluar el porcentaje de HP en esta población igualmente la sensibilidad de las biopsias de distintas áreas del estómago. Métodos: Se tomaron biopsias del antro y del cuerpo gástrico para estudio histológico y biopsias del antro y cuerpo para procesarse juntas en una prueba rápida de la ureasa (HpTest). Se consideró infectados por HP a los pacientes con al menos una prueba positiva. Se registró la exposición a terapia previa contra HP, inhibidores de bomba de protones (IBPs), bismuto, y antibióticos. Resultados : La prevalencia de HP fue 38.5 por ciento. En pacientes con dispepsia no expuestos a los factores estudiados fue 44 por ciento. La sensibilidad de los exámenes fue: Hptest: 84 por ciento, histología: 89 por ciento, biopsia antral: 64 por ciento, biopsia corporal: 79 por ciento. La exposición a IBPs disminuyó la sensibilidad de la biopsia antral a 44 por ciento. Discusión: La prevalencia que describimos es la menor reportada en Perú. Se evidencia su disminución en la población atendida en la CRP. La biopsia antral tiene baja sensibilidad, quees aún menor si hay exposición a IBPs. No es recomendable la biopsia exclusiva del antro para el diagnóstico.


Introduction: The prevalence of Helicobacter pylori in high and mid social-economic classes in Peru is trending down. This prevalence has not been evaluated at our institution inseveral years. The sensitivity of biopsies of the different anatomic areas of the stomach has not been evaluated either.Materials and Methods: Biopsies were taken from the antrum and body of the stomach for histologic evaluation. Biopsies were taken, one each, from body and antrum and were processedin the same sample for rapid urease test,(HpTest). HP infected patients were defined as those who had any of the three samples positive. Other variables evaluated were prior exposure toproton pump inhibitors, HP treatment, any other antibiotics, or bismuth subsalicylate. Results : The overall prevalence of HP was 38.54 percent. It was 44.04 percent in those not exposed to the evaluated variables. Independent sensitivities were HpTest:84.46 percent, Histology:89.86 percent. Sensitivities for antral and body biopsies were 64.86 percent and 79.73 percent, respectively. Exposure to proton pump inhibitors diminished the sensitivity of antral biopsies to 44 percent. Discusion: This is the lowest reported incidence of HP in Peru. This is clearly associated with the social economic class using our facilities. Antral biopsies have a low sensitivity, which is even lower with prior exposure to proton pump inhibitors. It is not recommended to use antral biopsies exclusively to diagnose HP infection.


Subject(s)
Humans , Biopsy , Helicobacter pylori , Incidence , Prospective Studies
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